NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans
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چکیده
منابع مشابه
Obesity and Pulmonary Function in African Americans.
BACKGROUND Obesity prevalence in United States (US) adults exceeds 30% with highest prevalence being among blacks. Obesity is known to have significant effects on respiratory function and obese patients commonly report respiratory complaints requiring pulmonary function tests (PFTs). However, there is no large study showing the relationship between body mass index (BMI) and PFTs in healthy Afri...
متن کاملPolymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among Afr...
متن کاملCommon Polymorphisms in the TLR4 Gene are Associated with Susceptibility to Pulmonary Tuberculosis in Sudanese
SETTING: Host genetic risk factors influence the susceptibility to tuberculosis (TB). There is ample evidence supporting the involvement of toll-like receptor 4 (TLR4) in mycobacterial infection. OBJECTIVE: To study the relationship between the TLR4 gene and TB susceptibility in Sudanese. DESIGN: A case-control study was conducted by recruiting 207 patients with pulmonary TB and 395 healthy con...
متن کاملPulmonary tuberculosis in African native troops.
Several important papers have been written describing various aspects of pulmonary tuberculosis in negro races (Dumas, 1919; Borrel, 1920; Opie, 1924 and 1930; Report on South African Natives, 1932; Allen, 1932; Everett, 1933; Pinner and Kasper, 1932; Cummins, 1939; Israel and Payne, 1940). An acute course, with a high incidence of gross glandular enlargement and of tuberculous pneumonia, is we...
متن کاملClubbing in African patients with pulmonary tuberculosis.
Finger clubbing was first discussed in association with pulmonary tuberculosis in 19151 but is not included as a feature of the disease in most modem textbooks of medicine. It has been our impression that clubbing is common in adult African patients with pulmonary tuberculosis, and we therefore studied the prevalence of this physical sign and related it to clinical features and nutritional state.
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ژورنال
عنوان ژورنال: Human Genetics
سال: 2009
ISSN: 0340-6717,1432-1203
DOI: 10.1007/s00439-009-0713-y